Drug Standards
Cayman Chemical TemozolomIde 10mg
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
Cayman Chemical TemozolomIde 25mg
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
Cayman Chemical TemozolomIde 100mg
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
![Medchemexpress LLC Decanoic acid, 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl ester | 74050-97-8 | MFCD00866706 | 99.7% | 530.11 g/mol | C31H41ClFNO3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242949.png-250.jpg)
Medchemexpress LLC Decanoic acid, 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl ester | 74050-97-8 | MFCD00866706 | 99.7% | 530.11 g/mol | C31H41ClFNO3 | 5 MG
Haloperidol decanoate is the decanoate ester of haloperidol, a butyrophenone-class antipsychotic. It is a long-acting, lipophilic ester used in research to model depot formulations and to study dopamine D2 receptor pharmacology. Supplied as a solid for analytical and preclinical use; consult the batch certificate of analysis for purity and storage instructions.
- Long-acting decanoate ester for depot formulation studies.
- Dopamine D2 receptor antagonist activity relevant to antipsychotic research.
- High purity suitable for analytical and preclinical applications.
- Available in small research quantities for dosing and formulation work.
- Refer to batch certificate of analysis for purity, identity, and storage details.
![Medchemexpress LLC (E)-N-[4-(3-chloro-4-(3-fluorophenyl)methoxy)anilino]-4-(dimethylamino)but-2-enamide | 848133-17-5 | MFCD26792555 | >98.0% | 574.0 g/mol | C31H29ClFN5O3 | 10 MM 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000246335.png-250.jpg)
Medchemexpress LLC (E)-N-[4-(3-chloro-4-(3-fluorophenyl)methoxy)anilino]-4-(dimethylamino)but-2-enamide | 848133-17-5 | MFCD26792555 | >98.0% | 574.0 g/mol | C31H29ClFN5O3 | 10 MM 1 ML
HKI-357 is an irreversible small-molecule inhibitor of EGFR and ERBB2 used as a research reagent to probe receptor autophosphorylation and downstream signaling pathways. It shows potent cellular activity (reported IC50s ~34 nM and 33 nM) and is provided as a solid or as a ready-to-use DMSO solution for cell signaling studies.
- Irreversible dual inhibitor of EGFR and ERBB2.
- Potent activity with IC50s around 34 nM and 33 nM.
- Suppresses EGFR autophosphorylation (Y1068) and downstream AKT and MAPK signaling.
- Available as 10 mM solution in DMSO or as solid quantities for flexible dosing.
- High purity, typically ≥98% (HPLC), suitable for research applications.
Medchemexpress LLC Hki-357 | 848133-17-5 | MFCD26792555 | 98.1% | 574.05 g·mol⁻¹ | C31H29ClFN5O3 | 1 MG
HKI-357 is a small-molecule, irreversible dual inhibitor of EGFR and ERBB2 tyrosine kinases intended for research use. It shows low-nanomolar potency and suppresses EGFR autophosphorylation and downstream signaling, making it useful for cellular and biochemical studies of EGFR/HER2 pathways.
- Irreversible dual inhibition of EGFR and ERBB2.
- Reported potency: EGFR IC50 ≈ 34 nM; ERBB2 IC50 ≈ 33 nM.
- Suppresses EGFR autophosphorylation at Y1068 and downstream AKT and MAPK phosphorylation.
- Supplied as a solid research compound with recommended cold storage for long-term stability.
- Molecular formula C31H29ClFN5O3; molecular weight 574.05 g·mol⁻¹.
U.S. Pharmacopeia Nystatin | 1400-61-9 | MFCD25541651 | 200 mg
Nystatin | 1400-61-9 | MFCD25541651 | 200 mg
Sigma Aldrich Fine Chemicals Biosciences Dacarbazine Related Compound A United States Pharmacopeia (USP) Reference Standard | 72-40-2 | MFCD00012704 | 50MG
Dacarbazine Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 162.58 | 72-40-2 | MFCD00012704 | 50MG
Sigma Aldrich Fine Chemicals Biosciences Thiamine hydrochloride European Pharmacopoeia (EP) Reference Standard | 67-03-8 | MFCD00012780 |
Thiamine hydrochloride European Pharmacopoeia (EP) Reference Standard | Mol Wt: 337.27 | 67-03-8 | MFCD00012780 |
Cayman Chemical Glycopyrrolate 10mg
A mAChR antagonist (Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively); induces relaxation of precontracted isolated human bronchi at 0.01, 0.1, or 1 µM; reduces post-prandial gastric antral motility in dogs at 0.01 mg/kg; inhibits salivation in a rat model of pilocarpine-induced sialorrhea (ED50 = 0.74 UG/kg)
Cayman Chemical ErythromycIn lactobIonate 10g
A macrolide antibiotic and water-soluble form of erythromycin; active against S. aureus and S. pneumoniae, as well as clinical isolates of group A streptococci (MICs = 0.6, 0.06, and 0.031 UG/ml, respectively); increases survival and reduces the number of lung CFUs in a mouse model of S. pneumoniae-induced pneumonia at 50 mg/kg; increases survival in mice infected with P. aeruginosa at 50 or 100 mg/kg
Echelon Biosciences Research Labs PIK-93 5 mg
PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIII at low-nanomolar range (IC50=19 nM). In addition, this compound is a potent inhibitor of PI3K in vitro (IC50=16 nM). This compound inhibits p110, p110, p110 with IC50s of 0.039, 0.59, 0.12 M respectively. PIK-93 hydrogen bonds to the backbone amide and carbonyl of Val882 and between its sulphonamide and Asp964. PI4KIII is esential for replication of numerous viruses P. falciparum. Inhibition of plasmodial PI4KIII has been proposed as an anti-malaria treatment. This item is non returnable
![Research Products International Corp Allopurinol [4-Hydroxypyrazolo-[3,4-d]pyrimidine], 150 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-A21000-150.02.JPG-250.jpg)
Research Products International Corp Allopurinol [4-Hydroxypyrazolo-[3,4-d]pyrimidine], 150 Grams
Allopurinol inhibits the enzyme xanthine oxidase, which is involved in the production of uric acid. Researchers may use allopurinol to manipulate uric acid levels in experimental settings, allowing them to study the metabolism and physiological effects of uric acid in various tissues and organs.
Allopurinol may be used in studies examining drug interactions or combination therapies. By understanding how allopurinol interacts with other medications or compounds, researchers can optimize treatment strategies and minimize potential adverse effects.
Allopurinol's mechanism of action extends beyond its inhibition of xanthine oxidase. Researchers may utilize allopurinol to probe the downstream effects of xanthine oxidase inhibition, including alterations in oxidative stress, inflammation, and purine metabolism pathways.
Cayman Chemical Ketoconazole 5g
A triazole antifungal agent; has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 UG/ml); inhibits fungal CYP51; inhibits human CYP3A4 (IC50 = 0.54 µM)